中国实用内科杂志2011，Vol.31Issue(3)：205-207,3.
自体造血干细胞移植治疗继发进展型多发性硬化36例疗效及预后影响因素分析
Autologous peripheral hematopoietic stem cell transplantation for treatment of multiple sclerosis in 36 cases: efficacy and prognostic factors analysis
摘要
Abstract
Objective To investigate the efficacy and prognostic factors of autologous peripheral hematopoietic stem cell transplantation (auto-HSCT) for treatment of secondary progressive multiple sclerosis (SPMS).Methods A total of 36 patients received subcutaneous injection with granulocyte colony-stimulating factor ( GCSF) for 4 ～ 6 days to mobilize hematopoietic stem cells and were then collected for peripheral blood mononuclear cells (PBMCs). CD34 + cell sorting was performed in 28 patients. The preparative regimen was BEAM ( carmustine, melphalan, teniposide and cytosine arabinoside). Results Clinical improvement was shown in 15 cases and stability in 5 cases. 14 cases recurred after auto-HSCT, Two cases were lost to follow-up. The expected relapse free survival (RFS) was 55％ at 88 months. In addition, optic nerve injury at the onset of MS was considered as a risk factor for unfavorable outcome of auto-HSCT. Conclusion Auto-HSCT is effective for long-term remission in patients with SPMS. Optic nerve injury may be a risk factor for unfavorable prognosis of auto-HSCT.关键词
多发性硬化/自体外周造血干细胞移植分类
医药卫生引用本文复制引用
苏力,冀冰心,董会卿,惠吴函,张普,徐娟..自体造血干细胞移植治疗继发进展型多发性硬化36例疗效及预后影响因素分析[J].中国实用内科杂志,2011,31(3):205-207,3.基金项目
北京市教育委员会科技发展面上项目(km200810025001) （km200810025001）
