中国实用内科杂志2011，Vol.31Issue(3)：211-212,2.
环孢素A治疗免疫相关性血细胞减少症血药浓度与疗效关系的研究
Blood concentration and therapeutic efficacy of cyclosporine A in treatment of immuno-related pancytopenia: a correlation study
邵媛媛 1付蓉 1王化泉 1邢莉民 1刘鸿 1阮二宝 1邵宗鸿1
作者信息
- 1. 天津医科大学总医院血液科,天津,300052
- 折叠
摘要
Abstract
Objective To investigate the correlation between blood concentration and efficacy of cyclosporine A (CsA) in treatment of immunorelated pancytopenia (IRP). Methods 50 IRP patients were recruited for analysis of correlation between blood concentrations and therapeutic efficacy of CsA. Results Among these IRP patients,the fasting blood concentration of CsA (C0) was (141.3 ± 97.0) μg/L, which increased to (C2)(437. 2 ±241.9) μg/L at 2 hours after medication with CsA. More patients with C2 ≥300 μg/L showed favorable therapeutic efficacy, discontinuation of blood-product transfusion, and ilium bone marrow hyperplasia than those with C2 ＜300 μg/L. Patients with C0≥90 μg/L showed significantly better efficacy and sternal megakaryocyte counts than those with C0 ＜90 μg/L. The level of blood urea nitrogen (BUN) in patients treated with concurrent CsA and azole antiungal agents was significantly higher than in those treated with CsA alone. Conclusion The blood concentration of cyclosporine is correlated with therapeutic efficacy in treatment of IRP. C2≥300 μg/L and C0≥90 μg/L of CsA were associated with a favorably better efficacy. Conventional dosage of CsA appears safe,while addition with azole antifungal agents may lead to kidney injury.关键词
免疫相关性血细胞减少症/环孢素A/血药浓度分类
医药卫生引用本文复制引用
邵媛媛,付蓉,王化泉,邢莉民,刘鸿,阮二宝,邵宗鸿..环孢素A治疗免疫相关性血细胞减少症血药浓度与疗效关系的研究[J].中国实用内科杂志,2011,31(3):211-212,2.
