昆明医学院学报2011，Vol.32Issue(2)：41-46,6.
CDK2、p27kip1蛋白与宣威地区非小细胞肺癌的关系
Relationship between Expression of CDK2 and p27kip1 Protein and Non-small Cell Lung Cancer in Xuanwei
摘要
Abstract
Objective To explore the relationship between the expressions of CDK2 and p27kip1 protein and biological behavior of non-small cell lung cancer in Xuanwei.Methods Immuneohistochemical method was used to detect the expressions of CDK2 and p27kip1 protein in lung cancer tissues and normal pulmonary tissues of patients with non-small cell lung cancer in Xuanwei and non-Xuanwei regions.Results The expression of CDK2 protein was situated in endochylema in cancer tissues.The expression of CDK2 protein was the highest in Xuanwei adenocarcinoma tissues and was higher than that in Xuanwei saqumouscarcinoma, non-Xuanwei saqumouscarcinoma, non-Xuanwei adenocarcinoma, and normal tissues (P ＜ 0.05).The expression of CDK2 protein in Xuanwei saqumouscarcinoma tissues was higher than that in non-Xuanwei saqumouscarcinoma tissues (P ＜ 0.05 ).The expression of CDK2 protein in non-Xuanwei adenocarcinoma tissues was higher than that in non-Xuanwei saqumouscarcinoma and normal tissues (P ＜ 0.05).But the expression of CDK2 protein in non-Xuanwei saqumouscarcinoma tissues had no statistical difference with that in normal tissues (P＞ 0.05 ).The expression of CDK2 had no correlation with clinical stage and the differentiation (P ＞ 0.05).The expression of CDK2 protein had a correlation with lymph node metastasis and histopathology type in the experimental group (P＜ 0.05).The expression of CDK2 protein had significant difference between adenocarcinomas in the experimental group and adenocarcinomas in the control group (P ＜ 0.05 ).The expression of p27kip1 protein was situated in endochylema of cancer tissues in the experimental group and control group.The expression of p27kip1 protein had no differences beween differenct regions (Xuanwei and non-Xuanwei) and different pathologic types.The expression of p27kip1 protein in normal lung tissues was higher than that in lung cancer tissues (P ＜ 0.05 ).The expression of p27kip1 had no correlation with clinical stages, the differentiation and histopathology type of non-small cell lung cancer (P＞ 0.05), but had correlation with lymph node metastasis (P＜ 0.05 ).There was a negative correlation between the expressions of CDK2 and p27kip1 protein ( P ＜ 0.05).Conclusions The expression of CDK2 protein in cancer tissues of patients in Xuanwei is higher than that in non-Xuanwei regions.The expression of CDK2 protein in adenocarcinoma tissues of patients in non-Xuanwei regions was higher than that in saqumouscarcinoma and normal tissues in non-Xuanwei regions.The expressions of CDK2 and p27kip1 proteins have correlation with lymph node metastasis.There is negative correlation between the expression of CDK2 and p27kip1 proteins in lung cancer tissues.关键词
非小细胞肺癌/CDK2蛋白/p27kip1蛋白/免疫组化Key words
Non-small cell lung cancer/ Xuanwei/ CDK2 protein P27kipl protein/ Immunohistochemistry.分类
临床医学引用本文复制引用
李晓明,黄云超,殷君太,叶联华,杨凯云,赵光强..CDK2、p27kip1蛋白与宣威地区非小细胞肺癌的关系[J].昆明医学院学报,2011,32(2):41-46,6.基金项目
云南省科技创新强省计划国际合作基金资助项目(2008CA030) （2008CA030）
云南省重点基金资助项目(2007C009Z) （2007C009Z）
