中国比较医学杂志2011，Vol.21Issue(3)：27-30,35,后插3,6.DOI:10.3969/j.issn.1671.7856.2011.03.007
鸡胚尿囊膜(HET-CAM)眼刺激替代试验对产品及原料评价的比较
Comparison of BET-CAM Eye Irritation Test for Products and Ingredients
邱璐 1李小林 1卞俐娜 1山口能宏2
作者信息
- 1. 上海出人境检验检疫局,上海,200135
- 2. 日本小林制药株式会社,大阪
- 折叠
摘要
Abstract
Objective To compare the adaptability of HET-CAM eye irritation test for products and ingredients.Methods Test 19 ingredients and 23 products by HET-CAM and Draize eye irritation protocol. Compare the data from in vitro and in vivo test. Result Compare in vitro data and in vivo data, The Kappa coefficient , sensitivity, specificity are 0. 826,100％ ,85.75 for ingredient. 0. 531,81.8％ ,77. 8％ for cosmetics as well. Conclusion HET-CAM eye irritation test can be used to be alternative test of Draize test. HET-CAM system is more suitable for ingredients test.关键词
鸡胚尿囊膜试验/Draize眼刺激试验/替代试验Key words
HET-CAM tset/ Draize eye irritation test/ Alternatives分类
医药卫生引用本文复制引用
邱璐,李小林,卞俐娜,山口能宏..鸡胚尿囊膜(HET-CAM)眼刺激替代试验对产品及原料评价的比较[J].中国比较医学杂志,2011,21(3):27-30,35,后插3,6.
