中国比较医学杂志2011，Vol.21Issue(3)：36-38,封3,4.DOI:10.3969/j.issn.1671.7856.2011.03.009
四氯化碳复合法诱导家兔肝纤维化模型的建立
Establishment of Hepatic Fibrosis in Rabbit Model by Injecting Carbon Tetrachloride and Drinking Ethanol Water
郭秋 1任克1
作者信息
- 1. 中国医科大学附属第一医院放射科,沈阳,110001
- 折叠
摘要
Abstract
Objective To establish a set of rabbit model of hepatic fibrosis, and summarize the experiences from the modeling process. Method 30 normal level rabbits were divided into two groups, 25 rabbits as the experimental group were given carbon tetrachloride and oil mixture by intraperitoneal injection; five rabbits of the control group were given the same dose of saline. At 4th、7th、10th、13th、16th Week ,2 ～4 rabbits from the experimental group and 1 from the control group were sacrificed to observe the degree of hepatic fibrosis. Result During the modeling, seven rabbits of the experimental group were dead; the entire control group was survived. The degree of hepatic fibrosis was aggravated gradually with modeling extended. Conclusion The method successfully established a set of rabbit model of hepatic fibrosis.关键词
肝纤维化/家兔/模型Key words
Hepatic Fibrosis/ Rabbit/ Model分类
医药卫生引用本文复制引用
郭秋,任克..四氯化碳复合法诱导家兔肝纤维化模型的建立[J].中国比较医学杂志,2011,21(3):36-38,封3,4.
