中国比较医学杂志2011，Vol.21Issue(3)：52-55,4.DOI:10.3969/j.issn.1671.7856.2011.03.013
导管体外端保护装置在大鼠长期腰蛛网膜下腔置管模型中的应用
A Device of Micro-catheter Protection for Chronic Lumbar Catheterization of the Spinal Subarachnoid Space in Rats
摘要
Abstract
Objective To develop a novel device for chronic lumbar catheterization of the spinal subarachnoid space in rat with a perfect protection of the external portion of catheter, and more convenient for repeat injection.Methods Pathogen-free adult male Sprague-Dawley rats were used in this study.Rats were divided into two groups (n = 12 each) randomly.Rota-rod test and Tail-flick test were introduced to assess motor and sensory function respectively at one day preoperative and 1st, 3rd, 7th day postoperative.To evaluate functionality of the catheter, 10 μL 2％ lidocaine was injected in the catheter at 1st, 3rd and 7th day post-catheterization.Results There were no mortality and overt paralysis in 2 groups.There is no significant difference in motor and sensory function between the two groups (P ＞ 0.05, T test).Most external portions were destroyed a few days post operation in control group, however in group with device, all the catheters worked well (P ＜ 0.05, x2 test)and lidocaine test showed that functionality of the micro-catheters were normal 7 days after catheterization.Conclusion The novel device was reliable and convenient for repeat injection with a perfect protection function of the external portion of catheter, meanwhile it provided a more ideal model for chronic study in anesthesia, analgesia, neurescience and relevant research.关键词
保护装置/蛛网膜下腔置管/大鼠Key words
Protection device/ Lumbar catheterization of the spinal subarachnoid space/ Rat分类
医药卫生引用本文复制引用
杜世伟,包新杰,冯铭,魏俊吉,郭旭,王任直..导管体外端保护装置在大鼠长期腰蛛网膜下腔置管模型中的应用[J].中国比较医学杂志,2011,21(3):52-55,4.基金项目
国家高技术研究发展计划(2006AA02A115). （2006AA02A115）
