中国实用儿科杂志2011，Vol.26Issue(4)：297-300,4.
新生儿低血糖性脑损伤磁共振成像动态变化研究
Dynamic changes of DWI compared with conventional MRI in newborns with hypoglycemic brain damage
姚丽 1富建华 1薛辛东 1王晓明 2黄万杰 1郭静1
作者信息
- 1. 中国医科大学附属盛京医院儿科,沈阳,110004
- 2. 中国医科大学附属盛京医院放射科,沈阳,110004
- 折叠
摘要
Abstract
Objective To evaluate the dynamic changes of diffusion weighted imaging (DWI) and conventional MRI in neonatal hypoglycemic brain damage. Methods Twenty neonates with hypoglycemic brain damage diagnosed by MRI from September 2005 to September 2008 were reviewed retrospectively. The clinical data were compared with the data from another 20 neonates with normal MRI findings after hypoglycemia(control subjects). Results Compared with control subjects, the case subjects had lower mean lowest blood glucose level(P ＜ 0.01 ).Case subjects' duration of hypoglycemia was longer than control subjects' (P ＜ 0.01 ). In case subjects, the first MRI scan was performed from 1 days to 11 days after hypoglycemia onset, the average being 3.8 days. The occipital and parietal cortex and white matter was involved most frequently, and occipital region was involved in 11 cases, parietooccipital region 8 cases, parietal region 1 case. All involved regions showed hyperintensive signals on DWI; normal signals on both T1WI and T2WI were seen in 12 cases; hypointensity on T1WI and hyperintensity on T2WI were seen in 6 cases. Eleven cases received second scan from 8 days to 15 days after first scan, the average being 11.4 days, 7 cases showed normal signals on DWI. While other 4 cases showed hypointensity. Hypointensity on T1WI and hyperintensity on T2WI were demonstrated in all 11 cases.Three cases was followed-up at 6 months of age, and MRI scan showed normal signals on DWI, hypointensity on T1WI and hyperintensity on T2WI. Conclusion The sites which show hyperintensive signals on DWI at the early stage of disease are consistent with the foci which show hypointensity on T1WI and hyperintensity on T2WI in subsequent follow-up by conventional MRI. This consistency suggests that DWI seems to be a sensitive early diagnostic measure for disease.关键词
弥散加权成像/低血糖脑损伤/新生儿分类
医药卫生引用本文复制引用
姚丽,富建华,薛辛东,王晓明,黄万杰,郭静..新生儿低血糖性脑损伤磁共振成像动态变化研究[J].中国实用儿科杂志,2011,26(4):297-300,4.
