摘要
Abstract
Objective By observing lung function changes of children with capillary bronchitis after the treatment of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution, access its influence upon airway resistance of children. Methods 93 children with capillary bronchitis were randomly divided into treatment group (with Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution) and control group. Shape changes of TBFV and changes of main indexes of lung function were observed. Results The TBFV of both groups showed narrowing down, abrupt aseending limb on breath curve, peak brought forward, and descending limb sunk like wave trough. After treatment, the shapes of TBFV of both groups were greatly improved. Comparing main parameters of two groups before treatment, there was no marked difference (P ＞ 0.05 ). After treatment, respiratory rate (RR), peak expiratory flow (PEF), respiratory system resistance (Rrs) , and functional residual capacity per kilogram weight (FRC/kg) were all reduced, difference being marked (P ＜ 0.05 ), while tidal volume per kilogram weight ( VT/kg ), inspiratory/expiratory (TI/TE), peak time of expiratory flow (TPTEF), time to peak ratio (TPTEF/TE), volume in peak time of expiratory flow (VPTEF), volume ratio in peak flow (PFV), MEFR with 75％ tidal volume/peak expiratory flow (25/PF), tidal expiratory interim flow velocity/tidal inspiratory interim flow velocity (ME/Ml ) and compliance per kilogram weight (Crs/kg)were all increased, difference being marked (P＜0.05). Compare treatment group with common group, obvious improvement was shown on airway obstruction main indexPFV, 25/PF and ME/MI, and compliance of lung, Rrs of airway resistance, and FRC/kg were obviously improved, the difference also being meaningful. Conclusion Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution shows marked clinical efficacy in improving airway resistance of children with capillary bronchitis.关键词
毛细支气管炎/肺功能/氨溴特罗口服液分类
医药卫生
