中国实用儿科杂志2011，Vol.26Issue(4)：264-268,5.
呼出气一氧化氮监测评估儿童哮喘病情临床价值研究
Primary investigation of fractional concentration of exhaled nitric oxide in asthmatic children
沙莉 1曹玲 1马煜 1李硕 1娄小尚 1陈育智1
作者信息
- 1. 首都儿科研究所附属儿童医院呼吸科,北京,100020
- 折叠
摘要
Abstract
s: Objective To investigate the level of exhaled nitric oxide in child asthma patients. Methods A total of 358 asthmatic children in our asthma clinic observed from October 2007 to August 2009 were divided into different groups as asthma attack group and non-attack group, and treatment group and non-treatment group. The therapy, attack symptoms and signs of them were recorded into clinical form. Tests of spiromety and FENO were performed at the same time. Results FENO in asthmatic children was 28.5( 15.5 ～ 55.0) × 10-9, there being no significant difference between male and female. FENO in asthmatic children older than 11 years was significantly higher than in normal children[36.0 (20.0 ～ 65.0) × 10-9,12.6(9.5 ～ 17.1 ) × 10-9, Z = -11.352, P ＜ 0.001 ]. FEN O in asthmatic children was positively correlated with age (r = 0.206, P ＜ 0.01 ), not related to asthma history course or FVC, but slightly negatively correlated with FEV1 and MMEF(r = -0.164,P ＜ 0.0l,r = -0.176,P ＜ 0.01). FENO in the group of asthma attack was significantly higher than the group of non-asthma attack [ 38.4 ( 16.7 ～ 59.1 ) × 10-9, 26.0 ( 15.0 ～ 51.0 ) × 10-9;Z = -2.327, 0.01 ＜ P ＜ 0.05] ;in the group of treatment it was significantly lower than in the non-treatment group [24.0( 13.0 ～ 48.5) × 10-9,31.0 (16.7 ～ 57.2) × 10-9, Z = -2.215,0.05 ＞ P ＞ 0.01]. By analysis with ROC in children older than 11 years, the cut-off point was 17.9 × 10-9, sensitivity was 0.802, specificity was 0.825. Seventy-seven out of the 96 asthmatic chil dren with normal lung function showed higher FENO and 15 out of them had asthma attack. Conclusion It is found that FENO in asthmatic children is significantly higher than in normal children. FENO is a useful method to identify non-specific inflammation in asthmatic children from the normal children. The patients who have asthma attack or non-treatment ones have a higher FENO. Higher FENO indicates bad control or even worse condition. Patients who have no symptoms but normal lung function still have abnormal FENO. The test of FENO can be used in asthma management and its control.关键词
儿童/哮喘/呼出气一氧化氮分类
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沙莉,曹玲,马煜,李硕,娄小尚,陈育智..呼出气一氧化氮监测评估儿童哮喘病情临床价值研究[J].中国实用儿科杂志,2011,26(4):264-268,5.
