中国临床药理学杂志2011，Vol.27Issue(3)：199-201,3.
活血益智片对血管性痴呆小鼠凋亡蛋白p53及caspase-3表达的影响
Effect of Huoxueyizhi slice on p53 and caspase-3 protein expression in hippocampus of vascular dementia mice
摘要
Abstract
Objective To observe the effect of Huoxueyizhi slice on memory impairment and expression of p53 and caspase -3 in hippocampus of vascular dementia ( VaD ) mice. Methods Vascular dementia (VaD) mice model was made by two times of transient ischemia and reperfusion of bilateral common carotid arteries plus tail bleeding. The memory test, p53 and caspase -3 protein expression in hippocampus of VaD mice treated with and without Huoxueyizhi slice(2. 24,4. 48,9. 96 g · kg-1) and hydergine (7. 8 mg· kg-1), continuous administration of 28 days, were measured. Results Compared with model group, Huoxueyizhi slice significantly improved memory impairment. Meanwhile, based on the determination in hippocampus through method of the western blot, Huoxueyizhi slice decreased the expression of the proapoptotic protein p53 and caspase -3. Conclusion Huoxueyizhi slice can exert antiapoptotic effect through regulating p53 and caspase -3 protein expression.关键词
血管性痴呆/活血益智片/记忆障碍/海马/凋亡分类
医药卫生引用本文复制引用
王丽红,文慧,齐越,贾冬,周绮,鄂蕴娟..活血益智片对血管性痴呆小鼠凋亡蛋白p53及caspase-3表达的影响[J].中国临床药理学杂志,2011,27(3):199-201,3.基金项目
沈阳科学技术计划基金资助项目(1091141-9-00) （1091141-9-00）
