大剂量甲氨蝶吟治疗原发性中枢神经系统淋巴瘤的血药浓度监测及不良反应分析OA北大核心CSCDCSTPCD
Plasma concentration and adverse drug reaction analysis of high-dose methotrexate in patients with primary central nervous system lymphoma
目的 分析大剂量甲氨蝶吟(HD-MTX)(抗代谢性抗肿瘤药)治疗原发性中枢神经系统淋巴瘤(PCNSL)的血药浓度特点,并对其血药浓度进行监测.方法 对本院收治的19例PCNSL患者,进行50例次HD - MTX化疗,并监测化疗后不同时间点MTX血药浓度,综合分析血药浓度特点及其与患者性别、年龄及MTX剂量的相关性,并分析不良反应的发生和处理.结果 MTX化疗后,利用亚叶酸钙(CF)解毒后,大部分患者MTX血药浓度能在66 h降至安全浓度(0.05…查看全部>>
Objective To study plasma concentration and adverse drugs reaction (ADR) of high - dose methotrexate ( HD - MTX ) administered in patients with primary central nervous system lymphoma (PCNSL) and to improve the efficacy and safety of HD - MTX administration. Methods A total 50 cases of HD - MTX were administered to 19 patients with PCNSL in our hospital, and these cases were collected from 2009/01 to 2010/07. The plasma samples were collected and the plasma…查看全部>>
崔向丽;林松;朱乐亭;武迎磊;赵志刚
首都医科大学附属北京天坛医院,药剂科,北京,100050首都医科大学附属北京天坛医院,神经外科,北京,100050首都医科大学附属北京天坛医院,药剂科,北京,100050邢台市第三医院药剂科,河北,邢台,054000首都医科大学附属北京天坛医院,药剂科,北京,100050
医药卫生
原发性中枢神经系统淋巴瘤甲氨蝶吟血药浓度药物不良反应
《中国临床药理学杂志》 2011 (3)
218-222,5
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