中国临床药理学杂志2011，Vol.27Issue(3)：187-190,4.
雌激素与雌激素受体在大鼠肝脏缺血再灌注损伤中的作用
Effect of estrogen and estrogen receptor in hepatic ischemia reperfusion injury in rats
摘要
Abstract
Objective To investigate the effect of estrogen and estrogen receptor in hepatic ischemia reperfusion injury in rats. Methods One hundred twenty healthy male SD rats were divided into 3 groups randomly: pseudo - operation group ( sham group), hepatic ischemia repedusion group(model), estrogen pretreatment plus hepatic ischemia repedusion group(test). To measured the serum levels of ALT and TNF -α,the expression of nuclear factor - κB ( NF - κB ) and estrogen receptor (ER).Results The expression of NF - κB and ER, the serum levels of ALT and TNF - α and the damage of liver tissue change little in sham group.The expression of NF - κB and ER, the serum levels of ALT and TNF -α and the damage of liver tissue in model and test groups increased significantly, but the expression of ER in test group were higher than model group significantly. The expression of NF - κB in model group were higher than test group. The damage of liver tissue in model group were severe than the test group evidently. Conclusion Estrogen pretreatment can significantly increase the expression of estrogen receptor, then alleviate hepatic ischemia reperfusion injury through decrease the expression of NF- κB and the serum levels of TNF- α.关键词
肝脏/缺血再灌注损伤/雌激素/雌激素受体分类
医药卫生引用本文复制引用
胡礼宏,韩新生,郭建荣..雌激素与雌激素受体在大鼠肝脏缺血再灌注损伤中的作用[J].中国临床药理学杂志,2011,27(3):187-190,4.基金项目
陕西省卫生厅科研基金资助项目(02D25) （02D25）
陕西省科技攻关基金资助项目(2002K10-G1) （2002K10-G1）
