疑难病杂志2011，Vol.10Issue(6)：435-437,3.DOI:10.3969/j.issn.1671-6450.2011.06.014
沙利度胺与NP方案联合治疗晚期非小细胞肺癌的疗效观察
The effect study of thalidomide combined with NP regimen for advanced non-small cell lung cancer
摘要
Abstract
Objective To observe the efficacy and toxicity in the patients with advanced non-small cell lung cancer( NSCLC ), treated with thalidomide plus vinorelbine and cisplatin( NP )or NP alone. To evaluate the change of VEGF in peripheral blood in patients with advanced NSCLC. Methods 56 patients with advanced NSCLC were divided randomly into trial group( n = 30 )and control group( n = 26 ), The trial group was treated with vinorelbine 25mg／m2 iv, on d1 and d8 , cisplatin 80 mg／m2 iv on d1 , and thalidomide 200 mg orally and daily from d1. The contral group received vinorelbine and cisplatin as above described. The VEGF was measured by ELISA. Results The overall response rate was 53.3％ in the trial group and 38.5％ in the control group ,there were no significant differences between the two groups( P ＞ 0.05 ). Patients in benefit in trial group had a remarkable decrease in the number of VEGF( P ＜ 0.05 )while patients in benefit in control group had little decrease in the number of VEGF( P ＞ 0.05 ).there were no significant differences in toxicities between the two groups( P ＞ 0.05 ). Conclusion Thalidomide combined with NP regimen can enhance curative effect in the near future and decrease the leval of VEGF in serum without increased toxicities.关键词
肺癌,非小细胞/沙利度胺/化疗/联合Key words
Lung cancer, non-small cell/ Thalidomide/ Chemotherapy/ Combination引用本文复制引用
李焱,杨敬敬..沙利度胺与NP方案联合治疗晚期非小细胞肺癌的疗效观察[J].疑难病杂志,2011,10(6):435-437,3.
