中国药房2011，Vol.22Issue(15)：1364-1366,3.
香椿子水煎剂的抗血栓作用研究
Antithrombotic Effects of Toona sinensis Seeds Decoction
金桂兰 1陈超2
作者信息
- 1. 三峡大学人民医院/宜昌市第一人民医院药剂科,宜昌市,443000
- 2. 三峡大学医学院药理学教研室,宜昌市,443002
- 折叠
摘要
Abstract
OBJECTIVE: To observe the antithrombotic effects of Toona sinensis seeds decoction.METHODS: The prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT)of normal rats were determined to induce rat venous thrombus model and wet weight of thrombus was determined.Blood stasis syndrome model was induced and the content of plasma thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-Keto-PGF1α), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) were investigated.RESULTS: T.sinensis seeds decoction 280, 700, 980 mg·kg-1 significantly prolonged PT, TT and APTT of rats.T.sinensis seeds decoction 700, 980 mg·kg-1 reduced wet weight of thrombus significantly (P＜0.01).T.sinensis seeds decoction 700, 980 mg·kg-1 could elevate 6-Keto-PGF1α level but didn't affect t-PA and PAI levels.CONCLUSION: T.sinensis seeds decoction has obvious antithrombotic effects.关键词
香椿子/水煎剂/大鼠/抗血栓分类
医药卫生引用本文复制引用
金桂兰,陈超..香椿子水煎剂的抗血栓作用研究[J].中国药房,2011,22(15):1364-1366,3.
