郑州大学学报（医学版）2011，Vol.46Issue(2)：182-185,4.
多排螺旋CT灌注成像对兔VX2肝癌血供的评价
Evaluation of multi-slice spiral CT perfusion on blood supply of rabbits model bearing VX2 hepatic carcinoma
摘要
Abstract
Aim:To assess the diagnostic value of Muhi-slice CT perfusion for blood supply evaluation of the rabbits VX2 hepatic tumors. Methods: VX2 hepatic carcinoma mass were implanted into the left lobe of liver of 30 rabbits via laparotomic route. Multi-slice CT enhancement and perfusion were performed in these rabbits at twenty-one day after implantation. The CT imaging features of the tumors were observed and the perfusion parameters were measured in the rim of the tumor, non-tumorous regions nearby the tumor and the normal liver tissues. Results: Twenty-five (83％) rabbits were sucessfully implanted with the tumor. The tumors which has smooth border were demostrated itself as the round-shaped tumors with hypodensity on plain CT scan,significantly tinge-enhancement on arterial phase, relatively hypodensity on portal phase and no enhanced in the zone of necrosis. Blood flow, blood volume, permeability surface, hepatic arterial fraction, hepatic arterial perfusion increased and mean transit time decreased in the rim of the tumor compared with those of the non-normorous regions nearby the tumor and the normal liver ( P ＜ 0.05). Conclusion: Multi-slice CT perfusion could evaluate the blood supply station of hepatic tumors in vivo by perfusion parameters.关键词
CT灌注成像/兔/VX2肝癌/血供Key words
CT perfusion/ rabbit/ VX2 hepatic carcinoma/ blood supply分类
医药卫生引用本文复制引用
周悦,高剑波,杨学华,张永高,岳松伟,曲艳红..多排螺旋CT灌注成像对兔VX2肝癌血供的评价[J].郑州大学学报（医学版）,2011,46(2):182-185,4.基金项目
国家"十一五"科技支撑计划基金资助项目2007BAI05B05 （）
