郑州大学学报（医学版）2011，Vol.46Issue(2)：231-234,4.
子痫前期患者胎盘组织中晚期糖基化终产物受体和P-选择素的表达
Expression of receptor of advanced glycation end products and P-selectin in placenta of preeclampsia patients
杨玲竹 1李亚敏1
作者信息
- 1. 郑州大学第一附属医院妇产科,郑州,450052
- 折叠
摘要
Abstract
Aim :To explore the role of receptor of advanced glycation end products (RAGE) and P-selectin in the development of preeclampsia (PE). Methods:SP method and RT-PCR analysis were used to detect the expression of RAGE and P-selectin protein and mRNA in placenta tissue from 40 cases of PE (20 cases of mild PE, 20 cases of severe PE) and 30 cases of normal term pregnant. Results: All groups showed RAGE and P-selectin positive pigmentation in the placenta.RAGE protein was mainly expressed in trophoblast cells, but there was a small amount in the vascular endothelial cells.P-selectin was mainly expressed in syncytiotrophoblast cells, vascular endothelial cells,and interstitial cells. There were significant differences among three groups on the expression of RAGE and P-selectin protein( F = 250.152 and 274. 044,P ＜0. 001 ) and mRNA( F =624. 550 and 708. 351 ,P ＜0. 001 ). Expression of RAGE and P-selectin mRNA was significantly higher in placenta tissue of PE group compared with that of control group ( P ＜ 0.05 ), the levels of severe PE group were higher than those of mild PE group ( P ＜ 0.05) , and there was a positive correlation between them of protein and mRNA expression ( r =0. 814 and 0. 796 ,P ＜0. 001 ). Conclusion:The high levels of RAGE and P-selectin in placenta tiusse in PE may be associated with the occurrence and development of PE, and both of them have synergies in the development of PE.关键词
晚期糖基化终产物受体/P-选择素/子痫前期Key words
receptor of advanced glycation end products/P-selectin/ preeclampsia分类
医药卫生引用本文复制引用
杨玲竹,李亚敏..子痫前期患者胎盘组织中晚期糖基化终产物受体和P-选择素的表达[J].郑州大学学报（医学版）,2011,46(2):231-234,4.
