南方医科大学学报2011，Vol.31Issue(3)：561-563,3.
免疫吸附治疗全身型重症肌无力的疗效及作用机制研究
Efficacy of immunoadsorption therapy in the treatment of myasthenia gravis and the mechanism
李麒麟 1谢富华 2罗永胜3
作者信息
- 1. 湖南省衡阳县人民医院神经内科,湖南,衡阳,421000
- 2. 广州医学院第二附属医院神经内科,广东广州510000
- 3. 深圳市福田区第二人民医院内科,广东深圳,518049
- 折叠
摘要
Abstract
To evaluate the effect of immunoadsorption therapy in patients with myasthenia gravis (MG) and explore the mechanism. Methods This investigation involved 20 patients with MG treated with immunoadsorption combined with hormonal therapy and another 20 with only hormonal therapy, and 15 healthy subjects served as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure the changes in serum tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18) after the treatments, and the therapeutic effect of the treatments was evaluated using clinical scores. Results The clinical scores were significantly decreased after immunoadsorption therapy, showing a significant difference from that in the hormonal treatment group (P<0.05). The serum TNF-a and IL-18 levels were significantly higher in the two patient groups than in the control group (P<0.05), but in the former two groups, their levels were significantly lower in immunoadsorption therapy group (P<0.01). Conclusion Immunoadsorption therapy eliminates the inflammatory cytokines and free radicals as well as the circulating autoantibodies to improve the clinical symptoms of MG.关键词
重症肌无力/免疫吸附/肿瘤坏死因子α/白介素-18Key words
myasthenia gravis/ immunoadsorption/ tumor necrosis factor-alpha/ interleukin-18分类
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李麒麟,谢富华,罗永胜..免疫吸附治疗全身型重症肌无力的疗效及作用机制研究[J].南方医科大学学报,2011,31(3):561-563,3.
