军事医学2011，Vol.35Issue(3)：211-213,3.
继发性甲状旁腺功能亢进症对肾性贫血的影响
Effects of secondary hyperparathyroidism treatment on renal anemia
马晓莉 1孙雪峰 1丁巍 2孙晓丹 3曹雪莹 1张冬 1陈香美1
作者信息
- 1. 解放军总医院肾内科,北京,100853
- 2. 辽宁省鞍山市中心医院肾内科,辽宁鞍山,114001
- 3. 北京市康复中心,北京,100144
- 折叠
摘要
Abstract
Objective To observe the effect of the secondary hyperparathyroidism(SHPT) treatment on renal anemia in hemedialysis patients. Methods Thirty-four patients with hemodialysis were given active vitamin D3 or parathyroid surgery to correct SHPT. According to the outcome of treatment, the patients were divided into two groups, group 1[ immunoreactive parathyroidism hormone(iPTH) ≥ 350 ng/ml after treatment], group 2( iPTH ＜ 350 ng/ml after treatment). Then the values of hemogobin(Hb), hematocrit (Hct), the dosage of recombinant human erythropoietin(r-HuEPO) and r-HuEPO dosage to Hct(EPO/HCT) were compared before and after treatment. Results After treatment, the iPTH dropped below 350 ng/ml in 25 patients( group 2) ,but was still well above 350 ng/ml in 9 patients( group 1 ). No difference was observed between the two groups in parameters before treatment. After therapy, Hb,Hct,and EPO/Hct of patients in group 2 were significantly increased compared to group 1. In group 2, iPTH was decreased from(739.03 ±411.77)pg/ml to (251.91 ± 72.9) pg/ml, Hb was increased from ( 104.32 ± 9.56) g/L to ( 116.44 ± 7.37 ) g/L, Hct was increased from (32.52 ± 2.8 ) ％ to(36.56 ± 2.08) ％, and the ratio of EPO/Hct was decreased from (4.36 ± 1.46) × 104 U to (3.47 ± 1.10) × 104 U, P ＜ 0.05. In group 1, before the treatment, iPTH, Hb, Hct and EPO/Hct ratio were (999.67 ± 351.99 ) pg/ml, (107 ± 11.41)g/L,(33.3 ±3.5)％ and (4.36 ± 1.46)％ vs (1029.3 ±281. 041) pg/ml, (106 ± 11.12)g/L, (32.8 ± 3.3)％ and (5.13±1.74) × 104 U,P＞0.05 after treatment. Conclusion SHPT is an important cause of EPO resistance. Correcting SHPT in hemodialysis patients could contribute to the treatment of renal anemia.关键词
血液透析/肾性贫血/甲状旁腺功能亢进症,继发性分类
医药卫生引用本文复制引用
马晓莉,孙雪峰,丁巍,孙晓丹,曹雪莹,张冬,陈香美..继发性甲状旁腺功能亢进症对肾性贫血的影响[J].军事医学,2011,35(3):211-213,3.
