中国药业2011，Vol.20Issue(7)：76-77,2.
氨磷汀防治奥沙利铂神经毒性的临床研究
Clinical Study of Amifostine for Preventing Oxaliplatin-Induced Neurotoxicity
陈旭烽 1王永辉 1楼建1
作者信息
- 1. 浙江省丽水市中心医院肿瘤内科,浙江,丽水,323000
- 折叠
摘要
Abstract
Objective To assess the clinical efficacy of amifostine in preventing neurotoxicity induced by oxaliplatin. Methods A total of 80 patients with colorectal cancer or gastric cancer were enrolled and randomly assigned to the experimental group (amifostine, 40 cases) and the control group(40 cases). All cases received the chemotherapy with FOLFOX4 regimen. The experimental group was given amifostine 8 mg, dexamethasone 5 mg amifostine 500 mg/m2 just before chemotherapy, while the control group was given only amifostine 8 mg and dexamethasone 5 mg. The neurological toxicity was assessed in each therapeutical cycle. Results Twenty- two point five percent cases in amifostine group occurred degree Ⅰ- Ⅱ peripheral neurotoxicity after 6 therapeutical cycles of chemotherapy, which was significantly lower than 47. 50％ in the control group( P＜0. 01). Seven point five percent cases in amifostine group occurred degree Ⅲ peripheral neurotoxicity,which was significantly lower than 17.50％ in the control group(P ＜0. 05). The occurrence rate of other adverse reactions had no obvious difference between the two groups. Conclusion Amifostine could prevent the occurrence of oxaliplatin- induced neurotoxicity and reduce its severity in the patients with digestive tract tumors.关键词
氨磷汀/奥沙利铂/神经毒性分类
医药卫生引用本文复制引用
陈旭烽,王永辉,楼建..氨磷汀防治奥沙利铂神经毒性的临床研究[J].中国药业,2011,20(7):76-77,2.
