南方医科大学学报2011，Vol.31Issue(3)：518-521,4.
卵巢癌肉瘤12例临床分析
Clinical analysis of 12 cases of ovarian carcinosarcoma
摘要
Abstract
To evaluate the clinicalpathological characteristics, treatment and prognosis of ovarian carcinosarcorma. Methods The clinical, pathological and follow-up data of 12 cases of ovarian carcinosarcoma treated in Cancer Center of Sun Yat-sen University from May, 2002 to May, 2009 were analyzed retrospectively. Results The 12 patients with ovarian carcinosarcoma had a median age of 55 years at diagnosis, among whom 10 were postmenopausal women. The patients sought medical attention for such symptoms as pelvic and/or abdominal pain, abdominal distention and ascites. Ten patients showed elevated serum CA125 level ad admission, and postoperative chemotherapy resulted in lowered CA125 level within normal range in 7 of them; in 8 cases, CA125 level increased with disease recurrence. Pelvic mass was found by such imaging examinations as CT, MRI and ultrasound in all cases. A definite diagnosis was obtained by postoperative pathological examination. All the patients received surgical resection and platinum-based adjuvant chemotherapy. Two patients achieved disease-free survival after the treatment. Disease relapse occurred in 10 cases within 2 years after surgery, among whom 2 showed disease remission after a secondary surgery and/or chemotherapy, and 1 was receiving chemotherapy; death occurred in 5 cases, and 2 cases were lost to the follow-up. Conclusions Ovarian carcinosarcoma has a poor prognosis. Primary surgery and platinum-based postoperative adjuvant chemotherapy is the main treatment for ovarian carcinosarcoma. The prognosis of ovarian carcinosarcoma is associated with the residual disease after surgery. The patients with disease recurrence may obtain remission and survival through a secondary surgery and/or chemotherapy. Serum CA125 can be used as a marker for monitoring the chemotherapeutic effect in clinical observation and follow-up visits.关键词
卵巢肿瘤/癌肉瘤/苗勒氏管混合瘤Key words
ovarian neoplasms/ carcinosarcoma/ mixed tumor, mullerian分类
医药卫生引用本文复制引用
朱安娜,李俊东,冯艳玲,徐漫漫,庄圆..卵巢癌肉瘤12例临床分析[J].南方医科大学学报,2011,31(3):518-521,4.基金项目
广东省科技计划项目(2009B030801021) （2009B030801021）
