实验动物与比较医学2011，Vol.31Issue(2)：96-101,6.DOI:10.3969/j.issn.1674-5817.2011.02.005
束缚应激致亚健康状态大鼠脑组织Bax、c-Fos的表达及中药干预作用
Expression of c-Fos and Bax in Brain Tissue of Sub-health State Rat Induced by Restraint Stress and Interventional Effect of Traditional Chinese Medicine
摘要
Abstract
Objective To observe the expression of Bax and c-Fos in brain tissue of sub-health state rat model induced by restraint stress, and further to study the effect of the Traditional Chinese Medicine.Methods Twenty male SD rats of 320-360g, were randomly divided into 4 with 5 rats per group:normal control group, model control group, Anti-ageing tablets group and Liuwei Dihuang pills group, 5 rats per group. The sub-health state animal model was established by limiting daily movement for 3 hours consecutive to 14 days according to the circumstance that can result human physiological stress. At the same time, the rats in Anti-ageing tablets group and Liuwei Dihuang pills group were treated with Anti-ageing tablets and Liuwei Dihuang pills. Respectively during the model building period. The expression level of Bax and c-Fos in brain tissues were detected on completion of the model establishment. Results Fourteen days after molding, in model control group,the expression level of Bax and c-Fos in cerebral cortex and in hippocampus was increased remarkably, while expression of Bax and c-Fos in anti-aging tablets and Liuwei Dihuang pills treated groups was decreased significantly (P＜0.05,P＜0.01). Conclusion The rat with mental stress were induced by activity restriction have got the expression of Bax and c-Fos significantly increased in brain tissue . The treatments of anti-aging tablets and Liuweidihuang pills improve this kind of mental stress through reducing the expression of Bax and c-Fos, protecting and decreasing neuron injuries caused by stressors.关键词
束缚应激/亚健康状态/大鼠/脑组织/Bax/c-Fos/中药分类
生物科学引用本文复制引用
刘瑞敏,冷晓霞,陈民利,潘永明,寿旗扬,周卫民,陶涛,朱科燕..束缚应激致亚健康状态大鼠脑组织Bax、c-Fos的表达及中药干预作用[J].实验动物与比较医学,2011,31(2):96-101,6.基金项目
1.浙江省中医"治未病"研究专项(2007WB022) （2007WB022）
2."浙江省卫生高层次创新人才培养工程项目"资助. （）
