实验动物与比较医学2011，Vol.31Issue(2)：137-139,146,4.DOI:10.3969/j.issn.1674-5817.2011.02.017
实验动物进口工作的实践和思考
卫振 1高翔 2丁贤明 1周天华 1刘迪文1
作者信息
- 1. 浙江大学,杭州310058
- 2. 杭州市出入境检验检疫局,杭州,310000
- 折叠
摘要
Abstract
The Goto-Kakizaki (GK) rat, one of the the best characterized animal models of spontaneous non-obese T2D, has similar progressive course with human. This animal is characterized by impaired glucose-induced insulin secretion, decreased beta cell mass, raised fasting blood glucose level,hepatic glucose overproduction and moderate insulin resistance in muscles and adipose tissues. Here, we review studies concerning genetic characterization, abnormal islet morphology, cytokines changes in some major tissues, such as islet, liver, muscles and adipose tissues, and the relationship of these changes and T2D etiopathology.关键词
实验动物/进口/隔离检疫分类
生物科学引用本文复制引用
卫振,高翔,丁贤明,周天华,刘迪文..实验动物进口工作的实践和思考[J].实验动物与比较医学,2011,31(2):137-139,146,4.
