同济大学学报（医学版）2011，Vol.32Issue(2)：58-61,4.DOI:10.3969/j.issn.1008-0392.2011.02.014
类风湿关节炎患者Th17细胞膜上RANKL的表达及意义
RANKL expression on Th17 cells in rheumatoid arthritis and its significance to clinic
摘要
Abstract
Objective To study the expression of blood and synovial fluid RANKL on Thl7 cells in patient with rheumatoid arthritis by analyzing the correlations between their expression level and the indexes reflecting RA disease and to elaborate the relationship between Thl7 cells and bone destruction.Methods Expression of RANKL on Thl7 cells from RA and control group was evaluated by flow cytometry and RT-PCR.Results Expression of RANKL on Thl7 cells was higher in RA blood than that in control group ( P ＜ 0.05 ), and it was higher in RA synovial fluid (P ＜ 0.05 ).There was a significantly positive correlation between expression of RANKL on Thl7 cells in peripheral blood of RA and DAS28 ( r= 0.36, P ＜ 0.05 ).Results from RT-PCR indicated that RANKL on CD4 + T cells was higher than that in control group ( P ＜ 0.05 ).A positive correlation was also found between RANKL mRNA and IL-17 mRNA on CD4 +T cell.Conclusion RANKL on Thl7 cells overexpresses in RA blood and synovial fluid, and has a significantly positive correlation with DAS28 in RA patients.Thl7 cells may be involved in the process of RA bone destruction, and may play an important role in RA immune pathogenesis of osteoclasts.关键词
类风湿/关节炎/Th17细胞/RANKL分类
医药卫生引用本文复制引用
范璐,陈海燕,韩捷,周洁如..类风湿关节炎患者Th17细胞膜上RANKL的表达及意义[J].同济大学学报（医学版）,2011,32(2):58-61,4.基金项目
上海市卫生局科研项目(2007165) （2007165）
