现代妇产科进展2011，Vol.20Issue(3)：207-209,3.
雌激素受体α在子痫前期胎盘的表达及临床意义
Expression and clinical significance of estrogen receptor alpha in placenta of preeclampsia
摘要
Abstract
Objective: To investigate the correlation between estrogen receptor alpha ( ERα/ER1 ) and preeclampsia and their significance through comparison of histological localization of FRα in placenta of pregnant women with preeclampsia and the normal pregnant women. Methods : The expression and histological localization of ERa was detected in placenta of 33 pregnant women with preeclampsia and 28 normal pregnant women by immunohistochemistry. Results: Immunohistochemistry showed that there were expressions of ERα in both groups. Additionally, the expressions of ERa in the cytoplasm or nucleus of cytotrophoblast in the group of pregnant women with preeclampsia were higher than that in the group of normal pregnant women ( P＜0. 05 ) . Conclusion : As the mediated central for ER , ERα in placental villous cytotrophoblast , villous capillary wall cells , and villous interstitial fibrosis fibroblasts may be involved in the occurrence and development of preeclampsia through regulating the function of ER.关键词
雌激素受体α/子痫前期/胎盘/免疫组织化学Key words
Estrogen receptorα / Preeclampsia / Placenta / Immunohistochemistry分类
医药卫生引用本文复制引用
杨洋,朱晓明,王珺,刘洪珍,尹国武..雌激素受体α在子痫前期胎盘的表达及临床意义[J].现代妇产科进展,2011,20(3):207-209,3.基金项目
国家自然科学基金资助项目(No:30973208 （）
31000660) （）
