癌变·畸变·突变2011，Vol.23Issue(2)：123-127,5.DOI:10.3969/j.issn.1004-616x.2011.02.010
联合检测Syk及nm23H1在大肠癌中的表达及其意义
Expression and clinical significance of combined detection on Syk and nm23H1 proteins in colorectal cancer
摘要
Abstract
OBJECTIVE: To investigate the expression of Spleen tyosine kinase (Syk) and of metastasis suppressor gene (nm23H1) and to determine the relationship between their expressions and clinico-pathological features and biological behavior in colorectal cancer. METHODS: Immunohistochemistry (SP) was used to detect the expressions of Syk and nm23H1 in 60 colorectal cancer tissues and normal colorectal cancer mucosa (5 cm distant to the margin of colorectal cancer and no microscopic cancer infiltration). RESULTS: The positive rates of Syk and nm23H1 proteins were 31.7％, 53.3％, respectively, in colorectal carcinoma tissues but 96.7％, 93.3％, respectively, in normal tissues (P ＜ 0.05). There was a significant difference in Syk and nm23H1 protein expression between lymph node metastasis,depths of invasion and Dukes stage(P ＜ 0.05), but not with sex, age, tumor size, lesion site and differentiation degree(P＞0.05). CONCLUSION: The expressions of Syk and nm23H1 proteins were lower in colorectal cancer tissues, suggesting that the Syk and nm23H1 genes may be closely associated with oncogenesis and malignant degree.Detection of Syk and nm23H1 may be used for early diagnosis, clinical therapy and prognosis of colorectal carcinoma.关键词
脾酪氨酸激酶/转移抑制基因/大肠癌/免疫组织化学Key words
Syk/ nm23H1/ colorectalcancer/ immunohistochemistry分类
医药卫生引用本文复制引用
张钧,孙国贵,付占昭,王雅棣,徐洪,顾涛..联合检测Syk及nm23H1在大肠癌中的表达及其意义[J].癌变·畸变·突变,2011,23(2):123-127,5.基金项目
河北省高等学校强势特色学科(群)项目(0727611012) （群）
