军医进修学院学报2011，Vol.32Issue(4)：308-309,316,3.
自体外周血造血干细胞移植治疗恶性血液病20例临床分析
Treatment of malignant hemopathy with autologous peripheral blood stem cell transplantation:Clinical analysis of 20 cases
徐丽昕 1曹永彬 1王志红 1闫蓓 1刘周阳 1刘蓓 1吴亚妹 1马健 1吴晓雄1
作者信息
- 1. 解放军总医院第一附属医院,血液科,北京,100039
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect of autologous peripheral blood stem cell transplantation(APBSCT) on malignant hemopathy. Methods Of the 20 patients with malignant hemopathy treated with APBSCT, 3 were diagnosed as acute leukemia, 1 as plasma cell leukemia, 8 as non-Hodgkin's lymphoma, 3 as Hodgkin 's lymphoma, and 5 as multiple myeloma. All patients treated with APBSCT in combination with MOEP plus G-CSF for PBSC mobilization. The median number of mononuclear cells (MNC) and CD34+ cells was (7.23 ± 2.27) × 108/kg and (4.37 ± 2.72) × 106/kg, respectively after PBSC was mobilized for 3-6 days. Results The hematopoietic function of patients was good after APBSCT. The mean time for the WBC and platelets to increase to >2.0 × 109/L and >20 × 109/L was 12.04 ± 1.76 days and 16.55 ± 2.31 days, respectively. Four patients died of relapse 6 months after APBSCT. The disease-free survival time of the remaining 16 patients was 6-55months. Conclusion APBSCT is a safe and effective procedure for malignant hemopathy.关键词
血液肿瘤/外周血造血干细胞移植/移植,自体Key words
Malignant Neoplasms/Peripheral Blood Hematopoietic Stem Cell Transplantation/Transplantation,Autologous分类
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徐丽昕,曹永彬,王志红,闫蓓,刘周阳,刘蓓,吴亚妹,马健,吴晓雄..自体外周血造血干细胞移植治疗恶性血液病20例临床分析[J].军医进修学院学报,2011,32(4):308-309,316,3.
