国际病理科学与临床杂志2011，Vol.31Issue(2)：177-180,4.DOI:10.3969/j.issn.1673-2588.2011.02.018
异柠檬酸脱氢酶1突变与人脑胶质瘤
Isocitrate dehydrogenase 1 mutations and human gliomas
摘要
Abstract
A recent cancer genome-sequencing project revealed that that novel point mutations in isocitrate dehydrogenase 1 (IDH1) in the majority of gliomas at WHO Grade II and III and secondary glioblastomas at grade IV. IDH1 mutations are early events in the development of gliomas,and are related with prolonged survival in gliomas at various grades. Mutated IDH1 shows an altered catalytic activity that results in the elevated levels of α-ketoglutarate and 2-hydroxyglutarate. The correhtions among the gliomas pathological diagnosis, tumor genesis, the therapeutic potential for targeting mutant IDH enzymes are discussed in this review.关键词
异柠檬酸脱氢酶/胶质瘤/病理诊断Key words
isocitrate dehydrogenase/ glioma/ pathological diagnosis引用本文复制引用
路平..异柠檬酸脱氢酶1突变与人脑胶质瘤 [J].国际病理科学与临床杂志,2011,31(2):177-180,4.
