军医进修学院学报2011，Vol.32Issue(4)：331-334,4.
血管紧张素Ⅱ受体拮抗剂治疗门静脉高压临床试验的Meta分析
Treatment of portal hypertension with angiotensin Ⅱ receptor antagonists: A meta-analysis of controlled trials
张昕 1谢杨新 2聂为民 2秦恩强 2陈威巍 2周志平 2赵敏2
作者信息
- 1. 军医进修学院,北京,100853
- 2. 解放军第302医院,感染性疾病诊疗研究中心,北京,100039
- 折叠
摘要
Abstract
Objective To assess the effectiveness and safety of angiotensin II receptor antagonists(ARB) in treatment of portal hypertension. Methods Controlled trials were retrieved from the Cochrane Library(Issue 3, 2010), PubMed, EBSCO, Springer, Ovid, Foreign Journals Integration System, CBMdisc and CNKI(from establishment to July 2010). References in retrieved articles were also retrieved. Randomized controlled trials(RCT) in which the effectiveness and safety of ARB used in treatment of portal hypertension were included in this study. The academic level of each retrieved trial was assessed by meta-analysis with the Rev Man 5 software. Results Of the 34 papers retrieved, 6 involving 246 patients and 6 parameters of RCT were finally included. Metaanalysis showed that the effect of ARB on hepatic venous pressure gradient(HVPG) was stronger in patients with portal hypertension than in controls(WMD=-1.62, 95% CI=-5.26 and 2.01, P=0.38). However, the incidence of adverse events was significantly higher in patients with portal hypertension than in controls(RR=3.78, 95% CI=1.31 and 10.96, P=0.01). Conclusion ARB can be used in treatment of portal hypertension with a limited effect and a high incidence of adverse events. More controlled studies with a large sample size are needed.关键词
血管紧张素Ⅱ受体拮抗剂/系统分析/高血压,门静脉/随机对照试验Key words
Angiotensin Ⅱ Receptor Blockers/Systems Analysis/Hypertension,Portal/Randomized Controlled Trial分类
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张昕,谢杨新,聂为民,秦恩强,陈威巍,周志平,赵敏..血管紧张素Ⅱ受体拮抗剂治疗门静脉高压临床试验的Meta分析[J].军医进修学院学报,2011,32(4):331-334,4.
