军医进修学院学报2011，Vol.32Issue(4)：366-368,377,4.DOI:CNKI:11-3275/R.20101112.1526.000
脂蛋白脂酶基因多态性与飞行员血脂水平的关系
Relationship between lipoprotein gene polymorphism and blood lipids in the pilots
摘要
Abstract
Objective To investigate the relationship between lipoprotein(LPL) gene polymorphism and serum lipids in the pilots. Methods The genotypes of LPL gene Hind Ⅲ , Pvu II and Ser447Ter sites were assayed by polymerase chain reaction-restricted fragments length polymorphism, and blood lipids were detected by stipulated methods on 106 pilots and 98 control subjects. Results There is no statistical difference in genotypes and alleles frequency of LPL gene Hind Ⅲ, Pvu Ⅱ and Ser447Ter sites in the pilots and control subjects. Hyperlipidemia prevalence (52.83%) of the pilots is much higher than that of the control (29.59%). There was a close relationship between different genotypes of LPL gene Hind Ⅲ and Ser447Ter site and levels of triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) in pilots, and there was a close relationship between different genotypes of Pvu Ⅱ site and levels of TG, total cholesterol (TC) and HDL-C. Conclusion LPL gene polymorphism is a genetic factor on the pilot individual serum lipid levels, and environment factors are important in inducing hyperlipidemia of the pilots.关键词
飞行员/脂蛋白脂酶/基因多态性/血脂Key words
Pilot/Lipoprotein Lipase/Gene Polymorphism/Lipid分类
特种医学引用本文复制引用
魏利召,蔡庆,刘红巾,陈涛..脂蛋白脂酶基因多态性与飞行员血脂水平的关系[J].军医进修学院学报,2011,32(4):366-368,377,4.基金项目
"十一五"全军医药卫生科研计划课题(08G045) （08G045）
空军"十一五"后勤科研计划空后医学领域项目(BKJ09J024) （BKJ09J024）
