基础医学与临床2011，Vol.31Issue(4)：458-462,5.
诱导多能干细胞建系过程中关键转录因子的作用
The functions of key transcription factors in the process of producing induced pluripotent stem cells
摘要
Abstract
It has made great breakthrough in the filed of stem cell study recently that people are able to induce cell reprogramming to gain induced pluripotent stem(iPS) cell in vitro via adding transcription factors, such as OCT4 and SOX2. Transcription factors ( OCT4, SOX2 and NANOG etc. ) play an important role in starting the cell reprogramming, maintaining the pluripotency of iPS cells and deciding whether it differentiates. Researching the mechanism of action of these transcription factors is beneficial to the further explanation of the molecular mechanism of the cell reprogramming.关键词
诱导多能干细胞/体外重编程/转录因子/OCT4/SoX2/NANOG/C-MYC/LIN28/KLF4Key words
induced pluripotent stem cell/ cell reprogrammingin vitro/ transcription factors/ OCT4/SOX2/NANOG/C-MYC/LIN28/KLF4分类
生物科学引用本文复制引用
罗虎,李泽桂..诱导多能干细胞建系过程中关键转录因子的作用[J].基础医学与临床,2011,31(4):458-462,5.基金项目
第三军医大学创新基金(2007XG42) （2007XG42）
