中国组织工程研究与临床康复2011，Vol.15Issue(15)：2773-2776,4.DOI:10.3969/j.issn.1673-8225.2011.15.027
缺血性糖尿病足部溃疡皮肤Vδ1T细胞胰岛素样生长因子1与诱生型一氧化氮合酶的表达
Expression of insulin-like growth factor 1 and inducible nitric-oxide synthase in Vδ1T cells from ischemic diabtetic foot ulcer skins
谢翠松 1薛耀明2
作者信息
- 1. 南方医科大学附属南方医院内分泌代谢科,广东省广州市,510515
- 2. 郴州市第一人民医院内分泌科,湖南省郴州市,423000
- 折叠
摘要
Abstract
BACKGROUND:Skin Vδ1T cells can secrete a series of cell factors that can promote wound healing, but the association between cell factors and nonunion in ischemic diabetic foot ulcer skin are rare reported.OBJECTIVE:To explore the association of expression of insulin-like growth factor-1 (IGF-1 ) and inducible nitric-oxide synthase (iNOS) in Vδ1T cells in ischemic diabetic foot ulcer skin.METHODS:Ten patients with ischemic diabetic foot ulcer and 10 healthy people were selected. The protein expression of IGF-1and iNOS was detected by Double-2 labeling immunofluorescence.RESULTS AND CONCLUSION:The protein expression of IGF-1 in Vδ1T cells was decreased in diabetic foot group than that of control group (P ＜ 0.01), but iNOS was increased than that of control group (P ＜ 0.01), which indicated that the decrease of IGF-1and the increase of iNOS in Vδ1 T cells correlated with ischemic diabetic foot ulcer healing.关键词
糖尿病足/Vδ1T细胞/胰岛素样生长因子1/诱生型一氧化氮合酶/氧化应激分类
医药卫生引用本文复制引用
谢翠松,薛耀明..缺血性糖尿病足部溃疡皮肤Vδ1T细胞胰岛素样生长因子1与诱生型一氧化氮合酶的表达[J].中国组织工程研究与临床康复,2011,15(15):2773-2776,4.
