摘要
Abstract
Objective:To investigate the changes of insulin resistance(IR) and function of islet β-cell function in gout patients with different status of glucose metabolism. To analysis metabolic features in gout patients with hyperglycemia. Methods:Ninety-six patients with gout were consecutively enrolled into the study. According to 75g oral glucose tolerance test results ,patients were divided into normal glucose tolerance group (NGT, n= 34),impaired glucose regulation group (IGR, n= 27) and diabetic group (DM, n= 35). Height, weight, blood pressure, fasting glucose, fasting insulin,glycosylated hemoglobin (HbA1c), serum uric acid, C-reactive protein , cholesterol and triglycerides were investigated in all subjects. Body mass index (BMI), homeostasis model insulin resistance index (HOMA-IR), pancreatic β-cell function index (HOMA-B) and insulin sensitivity index (ISI) were calculated. Results:Among three groups of DM,IGR and NGT, BMI((27. 36±4.10)、(25. 52±3.87)and(23. 64±3.19)kg/m2]、2hPG (18. 25±7.03) 、(10. 12±0.85)and(6. 75±0. 45) mmol/L]、fasting insulin (17. 58±6.35) 、(14. 92±5.72)and(8. 51±4.56)IU/ml]、glycosylated hemoglobin(10. 18±3.24)、(6. 54±3.28)and(5. 12±2.21)％]、cholesterol(5. 84±1.09)、(5. 23±0.97)and(4. 62±1.08) mmol/L]、triglycerides(3.93 ±1.23) 、(3. 09±1.01)and(2. 37±0.95)mmol/L]、C- reactive protein [(4. 98±2.02)、(3. 79±1.29)and(3. 07±1.26)mg/L]、 HOMA- IR[(1.80 ±0.06) 、(1. 72±0.20)and(0. 93±0.14)]were increased in the DM and IGR groups,although ISI was significantly decreased. HOMA-B[(87.6± 25. 1)、(126. 46±34.2)and(173. 75±32.1)] was significantly different between the three groups. Logistic analysis showed that age, BMI,SBP, triglyceride, ISI is independently associated with diabetes, but no correlation with uric acid. Conclusion The Gout patients with IGR mainly showed defect of insulin resistance the subjects with DM have more severe insulin resistance and defect of insulin secretion. Sever insulin resistance, β-cell dysfunction,increased BMI and C-reactive protein,lipud disorders, and hereditary susceptibility may be the mai metabolic features of gout with hyperglycemia.关键词
痛风/胰岛素抵抗/β细胞功能/糖代谢/C反应蛋白分类
医药卫生
