中国中西医结合影像学杂志2011，Vol.9Issue(3)：236-238,242,4.DOI:10.3969/j.issn.1672-0512.2011.03.014
原发性肝癌介入性靶向热化疗的临床应用研究
Clinical application of thermo-chemoembolization for primary hepatocellular carcinoma
摘要
Abstract
Objective :T o assess the clin ical efficacy and safety of therm o-chem oem bolization for the treatment of primary hepatocellu lar carcinom a .Methods :A to talof 41 cases of primary liver cancer were randomly divided into two groups :① transcatheter hepatic arterial chem oem bolization ( T A C E ) with heated liquid m ixed with chem icals and lipiodol group ( study group , n=20 ) ;②common TACE with non-heated mixture group (contcol group , n=21) .The tum or size of the two groups were 3-16 cm (mean 7.09 cm ) for the study group and 2.5-13 cm (m ean 7.43 cm ) for the controlgroup , respectively .The largest diam eter for the multlple tum ors were measured .The preoperative data including age , sex , tum or size , liver function , and KPS score of the two groups showed no statistical sign ficance ( P ＞0.05 ) .Patien ts pre and postoperative clin ical parameters such as symp tom , tum or marker (AFP ) , tum or images (CT or MRI) , liver function , survival tine , etc .were recorded .All patlents were followed up for 3-24 monthes .Results :Study group : median tum or size and AFP values before and after treatm en twere 30 cm 2 ,(1522.8±1067.1)ng/ml and 14.87 cm 2 , (355.6±321.4)ng/ml, respectively .W hile for the control group , these data were 56 cm 2 , (1164.5±891.4 )ng/ml and 44.8 cm 2 , (211.3±259.6 )ng/m l,respectively .The differences before and after treatrn ent were statistically signficant ( P ＜ 0.05) for the both groups.However, besides these two parameters , liver function change also showed no significance ( P ＞0.05 ) between these groups .The survival rate of 3 , 6 , 12 , 18 , 24 months of study and controlgroup were 100％ , 90％ , 75％ , 40％ , 20％ ; 100％ , 66.67％ , 42.68％ , 28.57％ , 9.52％ respectively , the difference was statistlcally significant ( P ＜ 0.05 ) .Conclusion : The efficacy of the therm o-chem oem bolization for the treatment of primary liv er cancer is better than that w ith common TACE without increasing the dam age of the liver .It can accelerate tum or necrosis and prolong survival.关键词
肝肿瘤/化学疗法,肿瘤,局部灌注/栓塞,治疗性分类
医药卫生引用本文复制引用
梁定,郭山峰,刘文贵,张元朝,沈湘蕾,柏成芳,马坤..原发性肝癌介入性靶向热化疗的临床应用研究[J].中国中西医结合影像学杂志,2011,9(3):236-238,242,4.基金项目
江苏省"六大人才高峰"第四批资助项目(编号:07-B-035). （编号:07-B-035）
