浙江医学2011，Vol.33Issue(5)：619-621,625,4.
nm23-H1基因遗传不稳定性和宫颈癌的相关性研究
Genetic instability of nm23-H1 gene in cervical cancer
摘要
Abstract
Objective To investigate nm23- H1 gene instability in cervical cancer and its correlation with clinical and pathological characteristics. Methods A total 146 cervicaltissue samples were collected from operation and biopsy, including 48 cases of CIN Ⅱ- Ⅲ, 48 cases of SCC, 50 cases of chronic cervicitis. The nm23-H1 proteins were detected by immunohistochemicalmethod. The nm23- H1 gene instability (include LOH and MSI) were examined by PCR- SSCP. The correlation of nm23- H1 gene instability with clinical and pathological characteristics of cervical cancer were anylyzed. Results The expression of nm23- H1 protein decreased with the progressing of cervical tumor. The LOH in nm23- Hl gene was more frequent in later stage cervical cancer. MSI was more frequent in CIN and early stage cervical cancer. The increase of LOH was related to the decreased nm23- H1 protein expression. Conclusion MSI and the LOH of nm23- H1 gene are detected in cervical cancer, which may be involved in the progress in cervical cancer with different mechanicals.关键词
nm23-H1基因/遗传不稳定性/宫颈肿瘤Key words
nm23- H1 gene / Heredity instability/ Cervicaltumor引用本文复制引用
王运根,陶萍萍,于爱军,单江静,郑伟平,高阳,黄雅琴..nm23-H1基因遗传不稳定性和宫颈癌的相关性研究[J].浙江医学,2011,33(5):619-621,625,4.基金项目
绍兴市科技局社会发展科研项目(2007A33007) （2007A33007）
