摘要
Abstract
Objective To understand the distribution and drug-resistance of gram-negative bactera isolated from lower respiratory tract in a hospital, so as to provide reference for anti-infection treatment in clinic. Methods Bacteria were isolated from sputum, bronchial aspiration, and pleural effusion of patients admitted in a hospital from January 2002 to December 2009, distribution and drug susceptibility test of bacteria were analysed retrospectively. Results A total of 9 884 isolates of bacteria were isolated during 8 years, 6 358 (64. 33％) of which were gramnegative bacteria . The main isolated bacteria were Pseudomonas aeruginosa (33. 41％), Acinetobacter spp. (20. 51％), K lebsiella spp. (19. 11％) , and Escherichia coli (12. 65 ％) . The main bacteria of Enterohacteriaceae had low resistance to carbapenems, such as meropenem and imipenem (＜3 ％), and had relative lower resistance to amikacin( 17. 37％ - 19. 58％), cefoperazone/sulbactam (10. 67％ - 23. 62％) , and piperacillin/tazobactam (13. 58％ -25. 11％). The resistant rate of Pseudomonas aeruginosa to carbapenems was up to 38. 54％ , and had relatively lower resistance to amikacin(31.50o％) and minocycline(32. 00％) ; Acinetobacter spp. had relatively lower resistance to carbapenems(10. 47 ％ ), levofloxacin (24. 64％) , amoxicillin/clavulanic acid (24. 33 ％), cefoperazone/sulbactam (27. 00％) , and minocycline( 10. 27％). Conclusion Gram-negative bacteria are the major pathogens in lower respiratory tract infection in this area, the main isolated bacteria have a rising resistance to most antimicrobial agents.关键词
下呼吸道感染/革兰阴性菌/抗药性,微生物/抗菌药物/病原菌分类
医药卫生
