中国感染控制杂志2011，Vol.10Issue(2)：132-135,4.
婴幼儿肺炎支原体感染免疫功能动态变化
Change in immunologic function of infants with Mycoplasma pneumonia infection
邓永超 1莫丽亚 1陈艳萍 1蒋玉莲 1张林1
作者信息
- 1. 湖南省儿童医院,湖南,长沙,410007
- 折叠
摘要
Abstract
Objective To investigate the change in immunologic function of infants with Mycoplasma pneumonic pneumonia (MPP) in the acute and recovery phase, and compare with normal healthy children. Methods Patient's peripheral blood was withdrawn respectively when they admitted in hospital within 2 hours in the acute phase (before receiving treatment with antimicrobial agents), having received macrolides for 2 - 4 weeks and when clinical and radiographic signs significantly improved , then all specimens were detected. Results Compared with healthy infants and infants in the recovery phase, the proportion of CD4 + T cells ,CTLA - 4 + T cells,CD4 + /CD8 +, NK cells and the level of C3,C4 in patients with acute MPP were significantly lower (P＜0. 05); the proportion of CD8 + T cells,B cells and the levels of IgA,IgM,IgE were significantly higher (P＜0. 05). The proportion of CD3 + T cells and the levels of IgG were not statistically different between two groups (P＞0. 05). Conclusion The immunologic function of patients are disordered in the acute phase of MPP, and still exist a certain degree of disorder during convalescence,immunological regulatory treatment should be given to infants with MPP , so as to reduce treatment course and improve convalescence.关键词
肺炎/婴幼儿/肺炎支原体/免疫反应/T淋巴细胞亚群分类
医药卫生引用本文复制引用
邓永超,莫丽亚,陈艳萍,蒋玉莲,张林..婴幼儿肺炎支原体感染免疫功能动态变化[J].中国感染控制杂志,2011,10(2):132-135,4.
