首页|期刊导航|中国神经再生研究（英文版）|Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction
中国神经再生研究（英文版）2011，Vol.6Issue(12)：914-918,5.DOI:10.3969/j.issn.1673-5374.2011.12.006
Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction
Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction
摘要
Abstract
This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson's disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinson's disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.关键词
Parkinson's disease/Xifeng Dingchan decoction/tyrosine hydroxylase/midbrain/behavior/Chinese herbal medicine/neural regenerationKey words
Parkinson's disease/Xifeng Dingchan decoction/tyrosine hydroxylase/midbrain/behavior/Chinese herbal medicine/neural regeneration引用本文复制引用
Enli Luo..Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction[J].中国神经再生研究（英文版）,2011,6(12):914-918,5.基金项目
This study was financially sponsored by Projects of Heilongjiang Province Administration of Traditional Chinese Medicine,No.ZH04Z74 （）
Second-Class Award of Scientific Advancement of Heilongjiang Province Administration of Traditional Chinese Medicine in 2007. （）
