中国组织工程研究与临床康复2011，Vol.15Issue(15)：2707-2710,4.DOI:10.3969/j.issn.1673-8225.2011.15.012
骨性关节炎动物模型内侧副韧带的应力松弛
Stress relaxation of medial collateral ligament in an animal model of osteoarthritis
朴成东 1李新颖 2高明 2马洪顺3
作者信息
- 1. 吉林大学第二医院,吉林省长春市,130041
- 2. 吉林大学中日联谊医院,吉林省长春市,130031
- 3. 吉林大学南岭校区工程力学系,吉林省长春市130022
- 折叠
摘要
Abstract
BACKGROUND: Similar to other soft tissues, ligament has viscoelasticity. The stress relaxation and creep viscoelasticity of ligaments are based on human physiologic functions. Studies have demonstrated that osteoarthritis has effect on ligament mechanical property.OBJECTIVE: To compare stress relaxation theological properties of medial collateral ligament (MCL) between normal and osteoarthritis animal models, to determine the influence of osteoarthritis on MCL ligament stress relaxation characteristics.METHODS: Animal osteoarthritis models were prepared by closed joint Nick method. Each 10 MCL samples were taken from normal and osteoarthritis rats for stress relaxation experiments. The strain increase rate was 5％/S, and test duration was 7200 s,a total of 100 data were collected. The stress relaxation data, and change laws of curves, stress and time were observed. All data were analyzed by one linear regression.RESULTS AND CONCLUSION: The stress relaxation of the normal and model groups changed fast at the initial 600 s, followed by a slow decrease. The stress relaxation of the normal group at 7200 s was 4.69 MPa, and the model group was 0.29 MPa. The 7200 s stress relaxation quantity of the model group was obviously smaller than that of the normal group (P ＜ 0.05). The stress relaxation curves were changed in a log relationship. The knee osteoarthritis can decrease MCL stress relaxation, whichcinfluences LCL stress relaxation characteristics.关键词
应力松弛/骨性关节炎/内侧副韧带/流变特性/大鼠模型分类
医药卫生引用本文复制引用
朴成东,李新颖,高明,马洪顺..骨性关节炎动物模型内侧副韧带的应力松弛[J].中国组织工程研究与临床康复,2011,15(15):2707-2710,4.
