中国组织工程研究与临床康复2011，Vol.15Issue(15)：2825-2828,4.DOI:10.3969/j.issn.1673-8225.2011.15.040
骨钙素基因Hind Ⅲ多态性与福州地区汉族绝经后妇女骨密度的相关性
Correlation between Hind Ⅲ polymorphism of osteocalcin gene and bone mineral density in Han Chinese postmenopausal women in Fuzhou area
摘要
Abstract
BACKGROUND: Osteoporosis is a polygenic disease. The relationships between osteocalcin (OC) genotypes and bone mineral density (BMD) are different from regions and populations.OBJECTIVE: To investigate the relationship between OC genotypes and BMD in postmenopausal women, so as to explore the susceptibility gene of female postmenopausal osteoporosis in Fuzhou region.METHODS: The OC genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The BMD of lumbar spine, femoral neck, trochanter and Ward's triangle of 201 Han Chinese postmenopausal women were measured by dual energy X-ray absorptiometry.RESULTS AND CONCLUSION: The distribution of OC genotypes of Han Chinese postmenopausal women in Fuzhou followed the Hardy-Weinberg equilibrium (X2=2.29, p ＞ 0.05). The frequencies of OC polymorphism were HH genotype 5％, hh 46％, and Hh 49％, which was not significant different from those of Fuzhou, Beijing, Guangzhou and Taiwan (P ＞ 0.05), but obviously different from Japanese and Caucasians (P ＜ 0.05). There was a significant difference in BMD of trochanter between HH and hh genotypes (P ＜ 0.05), but the difference was not significant in vertebrae L2-4, femoral neck and Ward's triangular area. There is some association between OC genotypes and BMD in postmenopausal women possibly.关键词
绝经后骨质疏松/骨密度/骨钙素/多态现象/汉族/福州分类
基础医学引用本文复制引用
聂达荣,王和鸣,杨连梓,彭美玉,陈可..骨钙素基因Hind Ⅲ多态性与福州地区汉族绝经后妇女骨密度的相关性[J].中国组织工程研究与临床康复,2011,15(15):2825-2828,4.基金项目
2007年福建省教育厅资助项目(JA07128),骨钙素基因Hind Ⅲ多态性对绝经后妇女骨密度的影响. （JA07128）
