中国组织工程研究与临床康复2011，Vol.15Issue(15)：2838-2841,4.DOI:10.3969/j.issn.1673-8225.2011.15.043
利多卡因对心脏术后脑保护效果的Meta分析
Cerebral protection with lidocaine following cardiac surgery: A meta-analysis
王东进 1聂岭 2王映纯3
作者信息
- 1. 南京中医药大学中西医结合鼓楼临床医学院胸心外科,江苏省南京市,210008
- 2. 南京大学医学院附属鼓楼医院胸心外科,江苏省南京市,210008
- 3. 南方医科大学中医药学院,广东省广州市,510515
- 折叠
摘要
Abstract
BACKGROUND: Although cardiac surgery becomes more mature, the ratio of cognitive deficits after surgery is still remains high. Some reports showed that lidocaine has neuroprotective effect, but their results are not totally identical.OBJECTIVE: To assess the neuroprotective effect of lidocaine in cardiac surgery.METHODS: A systematic literature search of PubMed, Cochrane databases, CNKI and Ovid was performed to identify relevant prospective randomized studies. The therapeutic effect and difference were evaluated using the odds ratio, weighted mean difference and 95％ confidence interval. Review Manager Version 5 Software was used for the analysis of extracted data.RESULTS AND CONCLUSION: Seven literatures were searched, including 5 addressing neuropsychological testing before and after surgery and 2 concerning cerebral metabolism. The pooled statistics showed lidocaine could not decrease in cognitive deficits, but there was a statistically significant decline of cognitive deficits in younger subgroup, low dose subgroup (P ＜ 0.05). A decrease effect of lidocaine on Ca-jvO2, CERO2 and AVDL was observed during the whole CPB (P ＜ 0.05). The incidence of death and withdraw showed no significant difference. There is no sufficient evidence to prove lidocaine is neuroprotective. But used in appropriate dosage regimens in specific clinical situations, lidocaine has neuroprotective effect.关键词
利多卡因/Meta分析/心脏手术/脑保护/随机对照研究分类
医药卫生引用本文复制引用
王东进,聂岭,王映纯..利多卡因对心脏术后脑保护效果的Meta分析[J].中国组织工程研究与临床康复,2011,15(15):2838-2841,4.
