中国组织工程研究与临床康复2011，Vol.15Issue(15)：2842-2846,5.DOI:10.3969/j.issn.1673-8225.2011.15.044
放射性咀嚼肌损伤模型软组织病理改变及转化生长因子β1的表达
Pathological changes of soft tissues and transforming growth factor beta 1 expression in radiation masseter injury models
摘要
Abstract
BACKGROUND: Long-term radioactive ray accumulation leads to surrounding tissues fibrosis accompanied by limitation of mouth-opening, which seriously affects life quality of tumor patients. OBJECTIVE: To observe pathological change of soft tissues in rats with radiation masseter injury and the level of transforming growth factor β1 (TGF-β1) mRNA expression in vivo.METHODS: A total of 30 Wistar rats were randomly divided into control group (n=10) and radiated group (n=20). Radiated group were radiated with linear accelerator at a dose of 40 Gy. The pathological changes of vessels were observed under light microscope and electron microscope and expression of TGF-β1 was detected by RT-PCR. RESULTS AND CONCLUSION: The microvessel density of radiated group was obviously decreased than that of the control group (P < 0.01), but the mRNA expression of was higher than that in the control group (P < 0.01). It suggests that radiated injury can induce fibrosis to repair the radiated injury.关键词
放射损伤/大鼠/毛细血管损伤/转化生长因子β1/血管密度分类
医药卫生引用本文复制引用
沈宗泽,郑建金,贾暮云,董刚,李涛..放射性咀嚼肌损伤模型软组织病理改变及转化生长因子β1的表达[J].中国组织工程研究与临床康复,2011,15(15):2842-2846,5.基金项目
青岛市科技局重点基金项目(08-2-1-5-nsh).the Key Foundation of Science and Technology Bureau of Qingdao,No.08-2-1-5-nsh （08-2-1-5-nsh）
