中国普通外科杂志2011，Vol.20Issue(3)：257-260,4.
MAP3K10在胰腺癌中的表达及其意义
Expression and significance of MAP3K10 in pancreatic carcinoma
摘要
Abstract
Objective To study the expression of MAP3 K10 in human pancreatic carcinoma (PC) , and the relationship between MAP3K10 and human PC. Methods The expressions of MAP3K10 protein and mRNA in PC and adjacent non-tumorous tissues were detected by immunohistochemical staining, Western blot and quantitative Real-time PCR. Results ( 1 ) Immunohistochemical staining demonstrated that the number of positive staining ceils in pancreatic carcinoma (100％ strong positive) was notablely higher than that in matched adjacent non-tumorous tissues (only 25％ weak posive) (P ＜ 0. 05 ); (2) Western blot proved that the expression of MAP3 K 10 protein in 91.7 ％ of PC, which was higher than that in matched adjacent non-tumorous tissues; (3)qRT-PCR showed that the expression of MAP3 K 10 mRNA in PC was significantly higher than that in matched adjacent non-tumorous tissues (P ＜ 0. 01 ). Conclusions MAP3K 10 is abnormally activated in pancreatic carcinoma, might play an important role in the carcinogenesis and progress of pancreatic carcinoma, and is expected to become a new therapeutic target for pancreatic carcinoma.关键词
胰腺肿瘤/病理学/丝裂原活化蛋白3激酶10分类
医药卫生引用本文复制引用
林凡,王敏,洪晓泉,李旭,王欣,秦仁义..MAP3K10在胰腺癌中的表达及其意义[J].中国普通外科杂志,2011,20(3):257-260,4.基金项目
国家自然科学基金资助项目(81071775). （81071775）
