中国临床心理学杂志2011，Vol.19Issue(1)：1-3,3.
首发重症抑郁症的弥散张量成像研究:基于纤维束示踪的空间统计学分析结果
Investigation of White Matter with Tract-based Spatial Statistics in Patients with Major Depressive Disorder
摘要
Abstract
Objective: The present study aimed to evaluate changes of white matter in patients with major depressive disorder (MDD) by use of a novel method called Tract-Based Spatial Statistics(TBSS).Methods: Diffusion tensor imaging (DTI) was performed in 20 patients with MDD and 20 healthy controls.TBSS was used to analyze the DTI data.Results:Compared with healthy controls, fractional anisotropy(FA) values were significantly decreased in the white matter of the left anterior limb of the internal capsule(ALIC), the right parahippocampal gyrus and the left posterior cingulate cortex.Further analysis revealed that FA values in the ALIC were negatively correlated with the severity of depressive symptoms.Conclusion: The present results support the hypothesis that altered WM integrity, especially in the cortical-subcortical neural circuit, may contribute to the pathophysiology of MDD.Furthermore, these findings provide novel evidence that microstructural abnormalities in WM may occur early in the course of depression.关键词
重症抑郁症/弥散张量成像/白质/各向异性分类
医药卫生引用本文复制引用
朱雪玲,王湘,肖晶,廖坚,姚树桥..首发重症抑郁症的弥散张量成像研究:基于纤维束示踪的空间统计学分析结果[J].中国临床心理学杂志,2011,19(1):1-3,3.基金项目
国家自然科学基金(30670709 （）
30700236) （）
