中国临床心理学杂志2011，Vol.19Issue(1)：4-6,9,4.
慢性创伤后应激障碍患者的脑功能磁共振研究
A Functional Magnetic Imaging Study of Brain in Patients with Chronic Post-traumatic Stress Disorder
摘要
Abstract
Objective: To study the features of brain functional activation in patients with chronic post-traumatic stress disorder (PTSD). Methods: Seventeen miners with chronic PTSD resulting from a severe mining accident and 14 miners exposed to the same accident without PTSD underwent functional magnetic imaging (fMRI). Results: The PTSD group showed greater activation in left parahippocampal gyrus and lower activation in right precuneus than non-PTSD controls.As compared with the control group, the PTSD group showed greater activations in right parahippocampal gyrus, right fusiform gyrus, right inferior occipital gyrus, bilateral middle occipital gyri in response to negative pictures; and lower activation in left inferior parietal gyrus, left superior parietal gyrus, right postcentral gyrus, left cuneus, dorsolateral prefrontal gyrus than in response to neutral pictures. The non-PTSD controls showed greater activation in right precuneus and lower insular in response to negative pictures, than in response to neutral pictures. Conclusion: The change of the brain may reflect complex biological mechanism of PTSD symptoms, including insufficient processing of traumatic emotion and memory.关键词
创伤后应激障碍/磁共振成像/脑分类
医药卫生引用本文复制引用
张丽,郑会蓉,李卫晖,张燕,贺忠,李凌江..慢性创伤后应激障碍患者的脑功能磁共振研究[J].中国临床心理学杂志,2011,19(1):4-6,9,4.基金项目
国家自然科学基金(30830046,30670751) （30830046,30670751）
国家科技支撑计划项目(2007BAI17B02) （2007BAI17B02）
973计划项目(2006CB5000800,2009CB918303) （2006CB5000800,2009CB918303）
