中国真菌学杂志2011，Vol.6Issue(1)：5-9,5.
伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究
Combination of itraconazole and terbinafine in treating sporotrichosis and their in vitro antifungal activities against Sporothrix schenckii
王爱平 1高那 1刘伟 1万喆 1陈伟 1涂平 1李若瑜1
作者信息
- 1. 北京大学第一医院皮肤性病科,北京大学真菌和真菌病研究中心,北京,100034
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摘要
Abstract
Objective To evaluate the efficacy of the combination of itraconazole and terbinafine in treating sporotrichosis and against Sporothrix schenckii growing in both mycelial and yeast phases. Methods The combination of itraconazole (200 mg/d) and terbinafine ( 250 mg/d) was applied in the treatment of sporotrichosis. In vitro effects against Sporothrix schenckii in two growth phases were evaluated by checker-board method, and fractional inhibitory concentration ( FIC ) index was caculated to determine whether the interaction was synergistic, indifference, or antagonistic. Results Three patients failed in itraconazole therapy were cured with the combination of itraconazole and terbinafine. Synergistic interactions of itraconazole and terbinafine against Sporothrix schenckii in mycelial form and in yeast form,were observed to be 75％ and 70％ respectively ( P =0.50). Conclusions The combination of itraconazole and terbinafine is efficient and safe in treating sporotrichosis with perfect synergy.关键词
孢子丝菌病/伊曲康唑/特比萘芬/申克孢子丝菌/菌丝相/酵母相/联合药敏/协同作用分类
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王爱平,高那,刘伟,万喆,陈伟,涂平,李若瑜..伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究[J].中国真菌学杂志,2011,6(1):5-9,5.
