首页|期刊导航|中华医学杂志（英文版）|Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study
中华医学杂志（英文版）Issue(9)：1310-1315,6.DOI:10.3760/cma.j.issn.0366-6999.2011.09.007
Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study
Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study
摘要
Abstract
Background Various etiologies that contribute to the loss of pregnancy have been proposed. Despite the lack of established and uniform screening methods for recurrent pregnancy loss (RPL), there are several factors considered to be definite (or probable) causes of RPL. Data describing the etiological characteristics of RPL consist almost entirely of Caucasian populations. As we were interested in the Chinese population, the goal of this study was to determine the etiological characteristics of RPL in the Chinese patients.Methods The study was performed retrospectively by analyzing 1122 women with RPL. Patients were divided into three groups according to their number of pregnancy losses. Diagnostic tests included the following 9 critiria: parental genetics, uterine anatomy, autoimmune factors, alloimmune factors, thrombophilic factors, endocrine parameters, genital infection, toxoplasma, rubella, cytomegalovirus, herpes (TORCH) titers and RH blood groups. The criteria for abnormal results were defined before diagnosis.Results We found that 87.1% (977/1122) patients had no more than 3 abnormal aspects, and the proportion of total abnormal results was similar among groups. The prevalence of abnormal results for each test did not differ among groups,except in the cases of parental genetics, uterine anatomy and presence of mixed lymphocyte reaction blocking antibodies (MLR-Bf). Absence of MLR-Bf, as well as abnormally increased levels of CD3+CD19+ and CD56+CD16+ cells, was commonly detected in Chinese RPL patients.Conclusion Immunological disorders play an important role in RPL among Chinese patients.关键词
spontaneous abortion/etiology/diagnosisKey words
spontaneous abortion/etiology/diagnosis引用本文复制引用
MENG Li-li,CHEN Hui,TAN Jian-ping,WANG Zheng-hua,ZHANG Rui,FU Shuai ,ZHANG Jian-ping..Evaluation of etiological characteristics of Chinese women with recurrent spontaneous abortions: a single-centre study[J].中华医学杂志（英文版）,2011,(9):1310-1315,6.基金项目
The study was funded by National Natural Science Foundation of China (No.81000259),Natural Science Foundation of Guangdong Province (No.10451008901004246),Research Fund for the Doctoral Program of Higher Education of China (No.20090171120075) and Youth Foundation of Sun Yat-sen University (No.2007016). （No.81000259）
