中国医科大学学报2011，Vol.40Issue(1)：60-63,4.
乳腺导管内增生性病变p53外显子突变的研究
Mutation of p53 Exon in Breast Intraductal Proliferative Lesions
摘要
Abstract
Objective Although p53 mutation is one of the most common alterations identified in invasive breast carcinomas,it is not clear whether its alteration frequently occurs in intraductal proliferative lesions including usual ductal hyperplasia (UDH),atypical ductal hyperplasia ( ADH ) and ductal carcinoma in situ (DCIS). The aim of this study is to investigate the p53 mutation in intraductal proliferative lesions,and clarify its significance in breast carcinogenesis. Methods p53 mutation was examined in 122 cases of noninvasive breast lesions including UDH, ADH and DCIS by high-resolution melting (HRM), followed by DNA sequence. Results The positive rates of p53 mutation were 0.0％,10.7％ and 22.6％ in UDH,ADH and DCIS,respectively. Conclusion p53 mutation occurs in intraductal proliferative lesions including ADH and DCIS,and might be an early event in breast carcinogenesis.关键词
乳腺导管内增生性病变/p53突变/高分辨率熔解/DNA测序分类
医药卫生引用本文复制引用
毛晓韵,范垂锋,魏晶,刘崇,姚凡,金锋..乳腺导管内增生性病变p53外显子突变的研究[J].中国医科大学学报,2011,40(1):60-63,4.基金项目
国家自然科学基金资助项目(30950009) （30950009）
