中国畜牧兽医2011，Vol.38Issue(1)：54-57,4.
朊蛋白生理功能的研究进展
The Research Progress of Physiologic Function of Prion Protein
谭荣荣 1刘爱林 2赵德明1
作者信息
- 1. 中国农业大学国家海绵状脑病实验室,北京100193
- 2. 河北省邯郸市动物疫病预防控制中心,河北邯郸056005
- 折叠
摘要
Abstract
Prion protein(PrPc)has received great attention as the major associated pathogenic agent, although a great deal has been known about the role of PrPc in the process of disease, the normal function of PrPc still remain elusive. In the present study, a variety of functions have been proposed for mammalian PrPc. Such as nucleocytoplasmic isoforms of PrPc, interactions with ligand and Cu2+, and can be acquired by plasm membrane using endocytosis and internalization. PrPc has multiple physiological functions, including protection of nerve system,assitance of cell death, differentiation and adhesion, and transduction of cell signaling. Thus, overview of the physiological function of PrPc will contribute to the cure of prion disease and further research of prion protein.关键词
朊蛋白/PrPc/生理功能分类
生物科学引用本文复制引用
谭荣荣,刘爱林,赵德明..朊蛋白生理功能的研究进展[J].中国畜牧兽医,2011,38(1):54-57,4.
