中药材2011，Vol.34Issue(1)：71-74,4.
育亨宾碱的正离子电喷雾离子阱质谱研究
Study on Yohimbine in Positive Mode by Ion Trap Mass Spectrometry
摘要
Abstract
Objective:The structure and fragmentation pathway of yohimbine were elucidated by electron spray ionization mass spectrometry (ESI-MS).Methods: Quasi-molecular ion peak m/z 355 [M + H]+ was detected by ESI-MS, and the main fragment ions of m/z 212 and m/z 144 were detected by ESI-MS2.Results:There are two main fragment pathway for m/z 355 [M + H]+ by ESI-MS2 and the fragment broken in pyridine ring.The full scan MS3 spectra of fragment m/z 212,and m/z 144 was obtained by ion trap mass spectrometry.The characteristic fragmentation was used to prove the structure of m/z 212,and m/z 144.The fragment routes of characteristic were discussed on the basis of ESI mass spectra.Conclusion: It can provide the experimental data for studying pharmacokinetics in vivo and modifying structure.关键词
育亨宾碱/电喷雾离子阱质谱/裂解途径分类
医药卫生引用本文复制引用
李鹏,陈琴华,陈富超..育亨宾碱的正离子电喷雾离子阱质谱研究[J].中药材,2011,34(1):71-74,4.基金项目
湖北省自然科学基金项目(2009CDB083) （2009CDB083）
湖北省教育厅科学技术研究项目(D20102108) （D20102108）
