中药材2011，Vol.34Issue(1)：77-80,4.
三七总皂苷对快速老化模型小鼠SAMP8脑内APP基因转录的影响
Effect of Panax notoginseng Saponins on APP Gene Transcription in the Brain Tissue of SAMP8
摘要
Abstract
Objective:To study the effect of Panax notoginseng saponins (PNS) on learning and memory ability and APP gene transcription in the brain tissue in senescence accelerated mouse prone 8 (SAMP8). Methods:SAMP8 were randomly divided into highdoes PNS group, low-does PNS group, huperzin A group and model group, the treatment groups were treated with the designed drugs respectively by intragastric administration for 4 consecutive weeks. The same volume of double distilled water was given to model group.After treatment, the abilities of learning and memory of the mice were tested with morris water maze, the mRNA content of APP was assayed by reverse transcription(RT) and real-time polymerase chain reaction (RT-PCR). Results: PNS could improve the abilities of learning and memory,high-does PNS could reduce the mRNA content of APP in the brain tissue of SAMP8. Conclusion:PNS can improve the abilities of learning and memory of SAMPS, the mechanism may be relevant to down-regulating the expression of APP gene at transcriptional level.关键词
三七总皂苷/快速老化模型小鼠/APP基因分类
医药卫生引用本文复制引用
钟振国,吕良,柴立民,吴登攀,张雯艳,黄金兰,高艺文,李菲,朱博..三七总皂苷对快速老化模型小鼠SAMP8脑内APP基因转录的影响[J].中药材,2011,34(1):77-80,4.基金项目
国家自然科学基金项目(30960489) （30960489）
